Potential relevance of shear stress for slit diaphragm and podocyte function
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چکیده
منابع مشابه
Hypoxia decreases podocyte expression of slit diaphragm proteins
BACKGROUND Chronic hypoxia contributes to progressive tubulointerstitial injury and, consequently, renal failure. However, the effect of hypoxia on glomerular podocytes, which are integral to the slit diaphragm complex and responsible for selectivity of the glomerular filtration barrier, has not been completely determined. METHODS Conditionally immortalized mouse podocyte cells were exposed t...
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Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a crosstalk between protein networks in different subcellular compartments. Proteins residing in the plasma membrane are internalized and transported as cargo in endocytic vesicles (i.e., endocytosis). Subsequently, cargo proteins can be delivered to lysosomes for degradation or recycled back to the plasma...
متن کاملWWC1 promotes podocyte survival via stabilizing slit diaphragm protein dendrin
Previous studies have indicated that glomerular podocyte injury serves a crucial role in proteinuria during the process of chronic kidney disease. The slit diaphragm of podocytes forms the final barrier to proteinuria. Dendrin, a constituent of the slit diaphragm protein complex, has been observed to relocate from the slit diaphragm to the nuclei in injured podocytes and promote podocyte apopto...
متن کاملEssential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling.
Integrin-linked kinase (ILK) has been implicated in the pathogenesis of proteinuria and congenital nephrotic syndrome. However, the function of ILK in glomerular podocyte in a physiologic setting remains unknown. In this study, a mouse model was generated in which ILK gene was selectively disrupted in podocytes by using the Cre-LoxP system. Podocyte-specific ablation of ILK resulted in heavy al...
متن کاملThe number of podocyte and slit diaphragm is decreased in experimental diabetic nephropathy.
PURPOSE To determine the number of podocyte, slit diaphragms, slit diaphragm extensions and GBM thickness in diabetic nephropathy. METHODS Sixty "Rattus Wistar"of both sexes weighing 200-300 g were divided in two experimental groups: normal group 10 animals, and alloxan diabetic rats--50 animals. Alloxan was administered in a single IV dose of 42 mg/kg body weight. Body weight, water and food...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2017
ISSN: 0085-2538
DOI: 10.1016/j.kint.2017.02.032